Due to it’s status of descriptive-observational study and quality improvement nature, patients will never be directly or indirectly intervened in any way, the human dignity of the participants will be intact, therefore  ethical conflict doesn’t play a role. However given that the gathered data will proceed from several medical centers and institutions from different countries, information will be treated with the utmost confidentiality in only one site server, data base and analysis will be done by the research unit’s Biostatistics specialist and data manager. Also, potentially identifiable information such as patient’s name, address will not be required from the hospital reporting the data.